Xiang Lyu

Motivated and detail-oriented undergraduate student pursuing a B.A. in Environmental Sciences at the University of Tokyo, with a strong interdisciplinary foundation in biology and chemistry. Experienced in both instructor-led and independently designed laboratory experiments involving microbial growth, gene expression analysis, spectrophotometry, and organic synthesis. Demonstrated ability to conduct original research, analyze data using Excel and bioinformatics tools, and clearly communicate scientific findings through written reports and presentations.

I am interested in the biology of aging, particularly the role of telomere attrition and telomerase dysfunction in age-related diseases. My current focus is on exploring gene therapy approaches that restore telomerase components—especially TERC—to combat telomere shortening, enhance chromosomal stability, and rejuvenate aging tissues. Inspired by  studies using AAV9-mediated transient expression of telomerase components in mouse models, I aim to investigate how reactivating telomerase can reverse degenerative phenotypes without triggering oncogenic transformation. A key challenge lies in balancing regenerative benefits with cancer risk, as telomerase overexpression is a hallmark in ~85% of cancers. Therefore, I am particularly interested in developing safe, transient, and tissue-specific telomerase gene therapies that minimize oncogenesis while promoting healthy aging.

• Until late July 2025: Available to work in the lab on Tuesdays and Thursdays for at least 4 hours a day.
• August to late September 2025: Unavailable due to summer break and travel abroad.
• From late September 2025 onward: Availability will depend on the upcoming semester's course schedule, which is not yet determined. However, I will ensure to be able to work in the lab at least 2 to 3 days a week, 4 hours a day.
• Weekend availability can also be arranged if needed.