Santosh Kumar Gothwal

A highly motivated, passionate, and trained molecular biologists with a strong scientific background in the areas including of chromosome structure formation, transcription, epigenetic regulation of transcription/DNA damage repair, regions specific DNA double-strand break formation in mitosis, meiosis, Immunoglobulin Class Switch Recombination and DNA damage response, whose career goal is to identify the complex multilayer mechanisms governing genome stabilities and cancer cell heterogeneity and translate the finding for development of novel human cancer therapeutics. A professional molecular biologist interested in finding out novel cancer therapeutic targets by investigation in the areas of DNA damage response, DNA replication stress and repair defects and ultimately develop novel approach that overcome the cancer cell heterogeneity and chemotherapeutic resistance, the barriers of human cancer treatments.

Publications and abstracts

• Gothwal, S.K., Patel, N.J., Colletti, M.M., Sasanuma, H., Shinohara, M., Hochwagen, A., Shinohara, A. The Double-Strand Break Landscape of Meiotic Chromosomes Is Shaped by the Paf1 Transcription Elongation Complex in Saccharomyces cerevisiae. Genetics. 202, 497-512 (2016).
• Ying Zhang, Takuya Suzuki, Ke Li, Santosh K. Gothwal, Miki Shinohara, and Akira Shinohara. Genetic Interactions of Histone Modification Machinery, Set1 and PAF1C, with the Recombination Complex, Rec114-Mer2-Mei4, in the Formation of Meiotic DNA Double- Strand Breaks. Int. J. Mol. Sci., 21, 2679; (2020)
• Krishnan V, Gothwal S, Dahuja A, Vinutha T, Singh B, Jolly M, Praveen S, Sachdev A. Enhanced nutraceutical potential of gamma irradiated black soybean extracts. Food Chem. 15; 246-253 (2018).
• Gothwal S.K.et. al., (2023) Histone acetyl reader protein BRD2 promotes AID induced Genomic instabilities during the B cell class switch recombination (Manuscript is to be submitted)
• Gothwal S.K., et al. (2023) Chemotherapeutic induced cell cycle specific gene expression in IgH-cMYC positive human Burkitt's lymphoma identifies MBD1 as a novel therapeutic target for the BCL6 amplified cancers (Submitted in Blood in January 2023, Gothwal SK- Corresponding author).
• Gothwal S.K. (2023) Gain of function mutant p53 R213Q derived human pancreatic cancer metastasis via CXCR5-overexpression (To be Submitted; Gothwal SK- Corresponding author)
• Gothwal S.K. (2023) DNA CpG methylation reader protein MBD1 maintains the sustained BCL6 levels in germinal center (GC) derived IgH-cMyc Burkiit's lymphoma and restricts Burkitt's lymphoma maturation during the humoral immune response (Gothwal SK- Corresponding author, planned to submit in 2023)
  Selected Abstracts
• Participated at the 9th Takeda Science Symposium on the theme “Towards understanding human development and Evolution (January 26-27, 2023, at Osaka Convention center, Japan)
• Presented my research work at 18th International p53 workshop in May 21-25 at Weizmann Institute of Science on the title " Polymorphic p53 P72R with R213Q mutation promoted the survival and proliferation of Human Burkitt's lymphoma via the CXCR5 dependent manner (First and corresponding author).
• Invited talk with title ' SARS-CoV2 and Human body; Perspectives from its genetics; Diagnostics to Therpaeutics, at the Indian Scientist Association of Japan Symposium, 2020.
• Oral talk ‘Histone acetyl reader protein BRD2 promotes AID-induced genomic instability' in 34th Radiation biology symposium at Kyoto University, Japan in November 2018.
• Oral talk in the annual meeting of Genetic society of Japan held at Keio University, Japan in 2013, entitled' Paf1 complex shapes the landscape of meiotic DNA break formation'.
• Oral talk in the annual meeting 3R (Replication, Recombination and Repair) held in Sendai, Japan, in year 2013, entitled ‘Paf1 complex regulates the formation and distribution of Meiotic DSB formation in Saccharomycescerevisiae.'
• Poster presentation and oral talk at the Institute for Protein Research, Osaka University, retreat in 2014, entitled ‘Roles of Paf1 complex in meiosis of Budding yeast'.
• Poster presentation at Molecular Biology Society of Japan meeting in Kobe, Japan 2014, entitled Roles of Paf1 complex in Meiotic DSB formation.

• Early career scientist grant (Kakenhi) by Japan Society for the Promotion of Sciences, 2021.
• Takeda Science Foundation award (2018- 1019) for studying the Mechanism of Genomic instability in B cell during antibody gene rearrangement'.
• National Overseas Scholarship for PhD abroad by Government of India (2010-2014).
• Ichiro Kanehara Science foundation awards (2018-2019) for Promotion of Medical Sciences for the study of Genomic Instability and B-Cell malignancy.
• Council for Scientific & Industrial Research (CSIR) Scholarship and National eligibility test in
  June 2008. The award assures the candidates to be eligible for assistantship during Ph.D. training in India & for lectureship in the national universities of India.

• Member of Japan Cancer Association since 2022 till now as presented the research work
• Member of Molecular Biology Society of Japan since 2012
• Member of Genetic Society of Japan since 2013
• Held the organizer committee position for hosting of international annual symposium of Indian Scientist association of Japan since 2019 till now.

References
Prof. Hisao Masukata (PhD Thesis Chief) Department of Biological Science, Graduate School of Science,
Osaka University, Japan. Telephone-81-6-6850-5432
Email- masukata@bio.sci.osaka-u.ac.jp

Prof. Akira Shinohara (PhD Supervisor)
Division of Integrated Protein Functions, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871 JAPAN Tel: 81-6-6879-8624; FAX: 81-6-6879-8626
E-mail: ashino@protein.osaka-u.ac.jp

Dr. Hiroyuki Sasanuma
Department of Radiation Genetics, Graduate School of Medicine,
Kyoto University, Japan.
Telephone- +81-75-753-4410: FAX : +81-75-753- 4419
Email- hiroysasa@rg.med.kyoto-u.ac.jp Telephone- +81-75-753-4410: FAX : +81-75-753- 4419
Email- hiroysasa@rg.med.kyoto-u.ac.jp