Summary
Overview
Work History
Education
Skills
Timeline
Generic

Lei Zhang

Ph.D. Candidate In Pharmaceutical Sciences | Analytical & Natural Product Chemistry
Kyoto

Summary

Ph.D. researcher in Pharmaceutical Sciences at Kyoto University, specializing in analytical and natural product chemistry. My work focuses on developing and validating analytical methods (HPLC, LC-MS/MS, NMR) for the structural elucidation of lysine-targeting covalent inhibitors from fungal metabolites. I have experience in stability evaluation under stress conditions, computational chemistry for molecular conformation analysis. My research integrates chemistry and biology to efficiently discover and advance bioactive compounds toward early-stage drug candidates.

Overview

3
3
years of professional experience
3
3
Languages

Work History

Ph.D. Researcher – Pharmaceutical Sciences

Kyoto University
04.2024 - 03.2027
  • Developed and validated analytical methods (HPLC, LC-MS, NMR) for the characterization of covalent enzyme inhibitors derived from fungal metabolites.
  • Designed and implemented an efficient screening workflow for fungal natural products, enabling the rapid identification of bioactive compounds with potential enzyme inhibitory activity.
  • Conducted stability evaluation under various environmental conditions (light exposure, solvent composition), identifying degradation pathways and optimizing storage conditions.
  • Performed computational chemistry simulations (Gaussian) to explore molecular conformations, supporting experimental structure elucidation.

Education

Ph.D. - Pharmaceutical Sciences

Kyoto University
Kyoto
04.2001 -

Master of Science - Pharmaceutical Sciences

Kyoto University
Kyoto
04.2001 -

Bachelor of Science - Agricultural Science

Meiji University
Tokyo
04.2001 -

Skills

    Analytical method development and validation (HPLC, LC-MS, NMR) for small-molecule inhibitors

    Structure elucidation combining spectroscopic data (NMR, MS, UV/ECD)

    Computational chemistry simulations

    Cell culture and Microbial culture

Timeline

Ph.D. Researcher – Pharmaceutical Sciences

Kyoto University
04.2024 - 03.2027

Ph.D. - Pharmaceutical Sciences

Kyoto University
04.2001 -

Master of Science - Pharmaceutical Sciences

Kyoto University
04.2001 -

Bachelor of Science - Agricultural Science

Meiji University
04.2001 -
Lei ZhangPh.D. Candidate In Pharmaceutical Sciences | Analytical & Natural Product Chemistry