DILIMULATI YIMITI

I have conducted a series of basic research studies on the musculoskeletal system, with a particular focus on tendon development and repair mechanisms, using genetically engineered mice and molecular biology techniques. I have also explored the pathogenesis of knee osteoarthritis (OA), a condition influenced by aging, genetics, obesity, and other factors. Through these efforts, I have gained proficiency in experimental techniques, including cell isolation and culture, isolation and characterization of extracellular vesicles, histopathological analysis, immunostaining, gene expression analysis, and the creation and analysis of mouse models. Beyond my own research, I actively participate in laboratory projects and collaborate with researchers from various fields.

2021 Apr. - 2022 Apr. Yahata Memorial Scholarship

2022 Apr. - 2023 Sep. Hiroshima University Next-Generation Fellow

2023 Apr. - 2023 Sep. Hiroshima University HU SPRING Research Grant

1. Yimiti, D.; Uchibe, K.; Toriyama, M.; Hayashi, Y.; Ikuta, Y.; Nakasa, T.; Akiyama, H.; Watanabe, H.; Kondoh, G.; Takimoto, A.; Shukunami, C.; Adachi, N.; Miyaki, S. CD1530, Selective RARγ Agonist, Facilitates Achilles Tendon Healing by Modulating the Healing Environment Including Less Chondrification in a Mouse Model. J Orthop Res. 2025, 43 (2), 273284.

2. Sumimoto, Y.; Harada, Y.; Yimiti, D.; Watanabe, C.; Miyaki, S.; Adachi, N. MicroRNA-26a Deficiency Attenuates the Severity of Frozen Shoulder in a Mouse Immobilization Model. J Orthop Res. 2024, 42 (12), 26232633.

3. Kono, N.; Kawasaki, R.; Oshige, A.; Nishimura, K.; Yamana, K.; Yimiti, D.; Miyaki, S.; Adachi, N.; Takabayashi, N.; Nagasaki, T.; Ikeda, A. Extracellular Vesicles Containing Fullerene Derivatives Prepared by an Exchange Reaction for Photodynamic Therapy. J Mater Chem B. 2024, 12 (38), 97609766.

4. Kawasaki, R.; Oshige, A.; Kono, N.; Yamana, K.; Hirano, H.; Miura, Y.; Yorioka, R.; Bando, K.; Tabata, A.; Yasukawa, N.; Sadakane, M.; Sanada, Y.; Suzuki, M.; Takata, T.; Sakurai, Y.; Tanaka, H.; Yimiti, D.; Miyaki, S.; Adachi, N.; Mizuta, R. Extracellular Vesicles Comprising Carborane Prepared by a Host Exchanging Reaction as a Boron Carrier for Boron Neutron Capture Therapy. ACS Appl Mater Interfaces. 2024, 16 (36), 4713747149.

5. Ding, C.; Yimiti, D.; Sanada, Y.; Matsubara, Y.; Nakasa, T.; Matsubara, K.; Adachi, N.; Miyaki, S. High-Fat Diet-Induced Obesity Accelerates the Progression of Spontaneous Osteoarthritis in Senescence-Accelerated Mouse Prone 8. Mod Rheumatol. 2023, 34 (4), 831840.

6. Kawabata, S.; Nakasa, T.; Nekomoto, A.; Yimiti, D.; Miyaki, S.; Adachi, N. Osteophyte Cartilage as a Potential Source for Minced Cartilage Implantation: A Novel Approach for Articular Cartilage Repair in Osteoarthritis. Int J Mol Sci. 2024, 25 (10), 5563.

7. Sanada, Y.; Ikuta, Y.; Ding, C.; Yimiti, D.; Kato, Y.; Nakasa, T.; Mizuno, S.; Takahashi, S.; Huang, W.; Lotz, M. K.; Adachi, N.; Miyaki, S. MiR-26a Deficiency Is Associated with Bone Loss and Reduced Muscle Strength but Does Not Affect Severity of Cartilage Damage in Osteoarthritis. Mech Ageing Dev. 2023, 212, 111806.

8. Kawasaki, R.; Kawamura, S.; Kodama, T.; Yamana, K.; Maeda, A.; Yimiti, D.; Miyaki, S.; Hino, S.; Ozawa, N.; Nishimura, T.; Kawamoto, S.; Ikeda, A. Development of a Water-Dispersible Supramolecular Complex of Polyphenol with Polypeptides for Attenuation of the Allergic Response Using a Mechanochemical Strategy. Macromol Biosci. 2023, 23 (4), e2200462.

9. Fujiwara, Y.; Ding, C.; Sanada, Y.; Yimiti, D.; Ishikawa, M.; Nakasa, T.; Kamei, N.; Imaizumi, K.; Lotz, M. K.; Akimoto, T.; Miyaki, S.; Adachi, N. MiR-23a/B Clusters Are Not Essential for the Pathogenesis of Osteoarthritis in Mouse Aging and Post-Traumatic Models. Front Cell Dev Biol. 2023, 10.

10. Sanada, Y.; Ikuta, Y.; Ding, C.; Shinohara, M.; Yimiti, D.; Ishitobi, H.; Nagira, K.; Lee, M.; Akimoto, T.; Shibata, S.; Ishikawa, M.; Nakasa, T.; Matsubara, K.; Lotz, M. K.; Adachi, N.; Miyaki, S. Senescence-Accelerated Mice Prone 8 (SAMP8) in Male as a Spontaneous Osteoarthritis Model. Arthritis Res Ther. 2022, 24 (1).

11. Shirakawa, Y.; Nakasa, T.; Kanemitsu, M.; Nekomoto, A.; Ishikawa, M.; Yimiti, D.; Miyaki, S.; Adachi, N. Therapeutic Effect of Targeting Substance P on the Progression of Osteoarthritis. Mod Rheumatol. 2022, 32 (6), 11751185.

12. Omoto, T.; Yimiti, D.; Sanada, Y.; Toriyama, M.; Ding, C.; Hayashi, Y.; Ikuta, Y.; Nakasa, T.; Ishikawa, M.; Sano, M.; Lee, M.; Akimoto, T.; Shukunami, C.; Miyaki, S.; Adachi, N. Tendon-Specific Dicer Deficient Mice Exhibit Hypoplastic Tendon through the Downregulation of Tendon-Related Genes and MicroRNAs. Front Cell Dev Biol. 2022, 10, 898428.

13. Hayashi, Y.; Yimiti, D.; Sanada, Y.; Ding, C.; Omoto, T.; Ogura, T.; Nakasa, T.; Ishikawa, M.; Hiemori, K.; Tateno, H.; Miyaki, S.; Adachi, N. The Therapeutic Capacity of Bone Marrow MSC-Derived Extracellular Vesicles in Achilles Tendon Healing Is Passage-Dependent and Indicated by Specific Glycans. FEBS Lett. 2022, 596 (8), 10471058.

1. Yimiti, D.; Sanada, Y.; Ding, C.; Nakasa, T.; Ishikawa, M.; Kamei, N.; Miyaki, S.; Adachi, N. Elucidation of the mechanism of obesity-induced age-related OA using aging-accelerated mouse model. The 36th Annual Research Meeting of the Japanese Orthopaedic Association; October 2021; Poster Presentation

2. Yimiti, D.; Miyaki, S.; Uchibe, K.; Nakasa, T.; Ishikawa, M.; Adachi, N. Therapeutic effect of retinoic acid receptor agonist on ectopic ossification during tendon repair. The 37th Annual Research Meeting of the Japanese Orthopaedic Association; October 2022; Oral presentation

3. Yimiti, D.; Uchibe, K.; Shukunami, C.; Nakasa, T.; Miyaki, S. Retinoic acid receptor agonist inhibits heterotopic ossification and promotes Achilles tendon repair. The 41st Annual Meeting of the Japanese Society for Bone and Mineral Research; July 2023; Oral presentation

4. Yimiti, D.; Miyaki, S.; Uchibe, K.; Nakasa, T.; Shukunami, C.; Adachi, N. Retinoic acid receptor agonist inhibits ectopic ossification and promotes Achilles tendon repair. The 38th Annual Research Meeting of the Japanese Orthopaedic Association; October 2023; Oral Presentation

5. Yimiti, D.; Uchibe, K.; Toriyama, M.; Hayashi, Y.; Ikuta, Y.; Nakasa, T.; Takimoto, A.; Akiyama, H.; Shukunami, C.; Adachi, N.; Miyaki, S. Local Administration of CD1530, Selective RARγ Agonist, Facilitates Tendon Healing by Modulating the Healing Environment Including Reduced Heterotopic Ossification in a Mouse Achilles Rupture Model. Orthopaedic Research Society 2024 Annual Meeting (US); February 2024; Poster